Posts tagged ‘Aaron Carroll’

Thinking About Risk

Kevin Drum preahces against the evils of teen tanning, which he follows with a conclusion that obviously Republicans are evil for opposing a tanning tax

Indoor tanning, on the other hand, is just plain horrifically bad. Aaron Carroll provides the basics:indoor tanning before age 25 increases the risk of skin cancer by 50-100 percent, and melanoma risk (the worst kind of skin cancer) increases by 1.8 percent with each additional tanning session per year. Despite this, the chart on the right shows the prevalence of indoor tanning among teenagers. It's high! Aaron is appalled:

This is so, so, so, so, so, so, so bad for you. Why don’t I see rage against this in my inbox like I do for diet soda? Why can’t people differentiate risk appropriately?

And who would fight a tax on this?

I am not going to get into the argument here (much) about individual choice and Pigovian taxes (by the way, check out the comments for a great example of what I call the Health Care Trojan Horse, the justifying of micro-regulation of our behavior because it might increase government health care costs).

I want to write about risk.  Drum and Carroll are taking the high ground here, claiming they are truly the ones who understand risk and all use poor benighted folks do not.  But Drum and Carroll repeat the mistake in this post which is the main reason no one can parse risk.

A key reason people don't understand risk is that the media talks about large percent changes to a small risk, without ever telling us the underlying unadjusted base risk.   A 100% increase in a risk may be trivial, or it might be bad.  A 100% increase in risk of death in a car accident would be very bad.  A 100% increase in the risk of getting hit by lightning would be trivial.

In this case, it's probably somewhere in between.  The overall lifetime risk of melanoma is about 2%.  This presumably includes those with bad behavior so the non-tanning number is likely lower, but we will use 2% as our base risk understanding that it is likely high.  The 5-year survival rate from these cancers (which by the way tend to show up after the age 60) is 90+% if you are white -- if you are black it is much lower (I don't know if that is a socio-economic problem or some aspect of the biology of darker skin).

So a teenager has a lifetime chance of dying early from melanoma of about 0.2%.  A 50% increase to this would raise this to 0.3%.  An extra one in one thousand chance of dying early from something likely to show up in old age -- is that "so, so, so, so, so, so, so bad"?  For some yes, for some no.  That is what individual choice is all about.

But note the different impacts on perception.

  • Statement 1:  "Teen tanning increases dangerous melanoma skin cancer risk by 50".
  • Statement 2:  "Teen tanning adds an additional 1 in 1000 chance of dying of skin cancer in old age."

Both are true.  Both should likely be in any article on the topic.  Only the first ever is included, though.

Of Course, the Left Takes No Ownership for This

from Kevin Drum

Today, Aaron Carroll tells us the story of TriCor, aka fenofibrate, a cholesterol drug licensed by Abbott Labs in 1998. Unfortunately, TriCor's patent was due to run out in 2000 and a maker of generic drugs was all set to produce a generic version. So Abbott sued, which delayed the generic version by 30 months:

In the interim, Abbott sought and obtained FDA approval for Tricor-2. That drug was nothing more than a branded reformulation of Tricor-1.Tricor-1 came in 67-mg, 134-mg, and 200-mg capsules; Tricor-2 came in 54-mg and 160-mg tablets. No new trials involving Tricor-2 were submitted to the FDA. But Tricor-2 came out while the generic company was still waiting to make Tricor-1, and thus Tricor-2 began selling with no direct competition.

Six months later, Tricor-2 evidently accounted for 97% of all fenofibrate prescriptions. By the time the generic copies of Tricor-1 came out, no one was taking it anymore, and they couldn’t penetrate the market.

Wash, rinse, repeat. The generic companies petitioned to make generic Tricor-2. Abbott filed a patent infringement suit buying them a 30 month delay. They got to work on Tricor-3. That tablet came in 48-mg and 145-mg doses. No new studies. They got approval. Evidently, 70 days after Tricor-3 was introduced, 70% of users were switched to the new branded drug. By the time the other companies got generic Tricor-2 out, Tricor-3 had 96% of the market.

Apparently, the entire moral blame for this accrues to Abbott, though he admits maybe physicians have some culpability for never prescribing the generic.

Really?  I have no particular desire to defend serial rent-seekers like Abbott, but the farce here seems to be in the regulatory system where small changes in what is essentially the packaging size allow companies to protect a government-enforced monopoly for their product.  Given the enormous difference in earnings between a monopoly product and one with a generic competitor, it is no surprise that Abbott is going to react to these incentives and use the system as presented to it.  In fact, if it did not, its executives would be making a huge ethical lapse in failing in their fiduciary responsibilities.

If you really think this is a corporate greed problem, then why is it that Apple doesn't keep competitors out of the smartphone market by making tiny tweaks to the screen size of the iPhone.  Wait, you say, screen size changes don't act as a barrier to competition?  Of course not.  But then why do changes in capsule size for a given chemical compound?  Because of the involvement of the government.

No, the problem here is not Abbott, the problem is a broken government regulatory system.  And you can pretty much count on Drum and his allies responding to anyone who actually tries to initiate a reform by streamlining this craziness by screaming that they just want to kill people by relaxing government regulations.