Archive for April 2021

Virological Calvinism

It is always dangerous when a non-religious person tries to make a statement about religious belief, especially when we get to complicated arguments about double predestination and supralapsarianism.  But for our limited purposes in this post, in Calvinism salvation and damnation are pre-ordained by God at the beginning of time --thus faith and good works have no bearing on being saved or damned.

I have come to believe that this is largely true of COVID-19, ie that the actions of man (at least as far as non-pharmaceutical interventions are concerned) have little or nothing to do with case rates and virus spread in any particular region.  Different geographies have different seasons for the virus, and trying to attribute low case rates or high case rates to the presence or lack of government interventions / restrictions is futile.  You can see that as location after location that was praised or damned at some point for its supposed good or bad handling of the virus have since seen opposite results.

There are a few exceptions to this, but very few.   On the positive side, the accelerated vaccine development programs were a near miracle, producing multiple viable vaccines WAY faster than I ever thought possible.  On the negative side, ordering infected people into long-term care facilities was a disaster.  But beyond these few exceptions, most of everything else didn't do squat.  The great regression analysis someone does someday on virus transmission rates across geographies is going to have seasonal variables, demographics, and urbanization with most of the explanatory power.

Quote of the Day on US Media Practices

From Glen Greenwald

Twice in the last year, I have written about this bizarre practice where media outlets purport to “independently confirm” one another's false stories by doing nothing more than going to the same anonymous sources who whisper to them the same things while providing no evidence. Yet they use this phrase “independent confirmation” to purposely imply that they obtained separate evidence corroborating the truth of the original story

This awful practice, which I see all the time, let's one anonymous source create a fictional narrative that dominates news cycles.

If you are not reading Glen Greenwald, you should.  When I recommend that a Marxist should be on your reading list, take that seriously.  If you don't want to pay, his work generally appears free a couple of days later on Zero Hedge and other places.  Today's quote is from today's email blast on yet another Russian conspiracy theory, crafted apparently to stop the US's overdue exit from Afghanistan, which now appears to have been almost completely fabricated.

2020 Should Have Been The Year We Demanded Reform of the FDA and CDC, But We Didn't. Now It's Come Back to Bite Us.

Many of the early failings in COVID response can be laid right at the doorstep of the CDC and FDA.

Shortages of testing?  The FDA refused to approve an tests except those developed at the CDC, and then the CDC tests failed.  Later, the FDA was really slow and conservative in approving new test approaches (eg home testing).

Shortages of PPE?  We learned that PPE manufacturers were all heavily regulated by the FDA, and FDA rules prevented quick ramp-ups, while liability rules made folks like 3M reluctant to shift N95 masks from non-medical to medical markets.

Slow vaccine rollout?  The FDA was its usual conservative self in approving vaccines, and refused to give any credit to vaccines approved by other western nations.  THEY had to approve it too.

First doses first?  No way, the CDC and FDA would not even consider it.   The conservative approach was to insist the vaccines be used exactly as originally tested, despite testing on the Pfizer vaccine showing that 1 dose of it was over 80% effective.  Now we see the world leader in reducing cases is the UK, which is the one country that did first doses first.

In a sane world, the CDC and FDA would have gotten hammered for what could be described as following peacetime rules in during wartime.  Add to that their ever-shifting and contradictory guidance, and guidance on NPI's that went against the sum of scientific research that had been published pre-2020, and you should have expected a LOT of media scrutiny of them in 202o.   Instead there was virtually none, and if anything the media fetishized and hero-worshipped these agencies.  Why?

As usual, the answer is Trump.  By 2020 the media was in the habit of blaming everything on Trump.  If COVID tests were in short supply, it must be Trump's fault.  No further scrutiny was needed.  In fact, no further scrutiny was wanted, because no explanation excerpt for "Trump's fault" was wanted.  Granted Trump helped them to some extent by his usual habit of off-the-cuff stupid statements.  But the media went ever further -- they wanted an anti-pole to Trump, and these agencies and morons like Dr. Fauci were elevated to sainthood not because they did anything right but because they could be portrayed as not-Trump.

For the media, whatever the FDA or CDC said represented scientific consensus.  Which is a horrible bastardization of science.  The FDA and CDC are not "science" and scientific "consensus", if such a thing is even real, is based on a quasi-antagonistic process of challenge and response between differing hypotheses (a process by the way the media actually undermined by de-platforming one side of many of the COVID-related debates) and not dictats by government agencies.  The FDA and CDC are populated by politicians and government bureaucrats who happen to have scientific degrees.  They are subject to all the same influences and bad incentives as any other political organization.  For example, in the government there are very different risk profiles between action and inaction.  Essentially, bureaucrats are seldom held accountable for deaths and harm from inaction -- if people die because they are slow to approve a new drug or procedure, no one puts that on them.  But they try to avoid at all costs approving something that eventually hurts someone, even if that harm is far less than the benefits of what they approved.  But instead of making all this clear, the media granted them the secular form of Papal infallibility.

So now we arrive at April 2021, and the FDA shut down the use of the J&J vaccine because it has about a 1 in a million chance of causing blood clots and a one in 6 million chance of causing a fatality.  People seem suddenly surprised that the FDA would do such a thing that is obviously so irrational (the number of lives saved by the vaccine is  -- by everyone's estimate -- orders of magnitude larger that those who have died from this side effect that may not actually even be due to the vaccine).

What is surprising to me is that anyone is surprised.  The FDA has ALWAYS acted this way.  Libertarians have called them out of this for years (thus, for example, libertarian-sponsored right to try laws).  In particular, failure after failure of COVID response in 2020 can be laid right at the FDA's doorstep, but we were just having too much fun demonizing Trump to actually look for root causes.  Well, now our inattention has come back to bite us with this absurd FDA decision.  The only good thing that can come from it is the potential that we might finally consider some reforms.

Prediction: Feds Will Be About The Last Government Entity To Drop Their Mask Mandate

Joe Biden is kind of stuck on COVID.  He campaigned on all the things Trump did wrong in his COVID response, but the only policy step of note that I can see that Biden has done differently is to issue a mask mandate for all federal property where Trump eschewed making NPI mandates at the Federal level, preferring to leave it to state and local governments based on their local conditions.  If this is really the case, expect Biden to be about the last man standing on government mask mandates, at least in the US.  My guess is that he will use continued cases or low vaccine rates in some state as an excuse to say that he can't drop the mandate until everyone in the US is ready  (forgetting how insane this is particularly when a more logical Federalist solution exists for the problem).

Biden is trying to claim credit for vaccination rates but it is hard to think of anything he has actually done to boost these rates since most all vaccines are administered by local folks and the vaccines were developed and funded on Trump's watch.  The only major decision Biden has made, which I actually think was a setback, was to declare that the US would not take a first doses first strategy used so successfully in the UK.  Biden has declared a goal of 100 vaccines in 100 days, but this is pretty much meaningless, the equivalent of a random dude running to the front of a parade and claim to be leading it.  Someone in his shop merely took a chart and of vaccination rates and projected it forward and determined about 100 million looked like they would be done in 100 days and so adopted this as a goal, hoping to retroactively convince people they caused this rather than just predicted it.  I would love someone in the press to ask Biden to name three things his Administration did that measurably accelerated the vaccination pace.

Like many, I find Trump irritating and distasteful and I have trouble saying nice things about him but he got a range of vaccines funded and got the US first in line for doses by pre-paying.  Its hard to think of anyone else who did more to help the crisis.  This helps me forget things like the botched testing development, which was really the FDA's and the CDC's fault but a different leader might have kicked those agencies out of their obstinate blocking role and into a more productive mode.

UPDATE:  I will add that the recent CDC / FDA decision to stop the J&J vaccine due to a 1 in a million non-fatal side effect seems like a terrible decision.  Again, possibly not Biden's decision, but like my criticism of Trump and testing, Biden could exercise some leadership here.  This is the price for fetishizing the CDC and FDA as all-knowing consensus voices of "science" that are not to be doubted, even to the point of having heterodox youtube videos taken down.  Because 1) These guys like Fauci are not scientists per se, but government bureaucrats with science degrees.  And as I have written many many times, government employees have incentives that lead to high risk aversion for acts of commission and low risk aversion for acts of omission.  Which means they put much higher weight on a death from a very easy to count and identify side effect that they could have stopped by stopping the vaccine than they do on deaths that are impossible to count or to see that were caused by the vaccine delay.  And 2) the idea of "scientific consensus" is a chimera and a term only used by non-scientists and a small group of government scientists that want to wield their position as a club to exercise power.  Seriously, how does such a consensus even exist if one side never was allowed to debate?  This is consensus as defined by Stalin or Mao.

We Knew About the Disproportionate Danger of COVID to the Elderly From The Very Beginning

In some recent debates over the Great Barrington Declaration, critics of that proposal argued that we didn't know that COVID was only a relatively small threat to healthy people under 65.  But we did know, as early as April or at worst May.  I know I was writing about it.  Just think of all the articles you have read with the theme of "everyone, not just old people, need to be terrified of COVID" and then look at this:

People over 65 make up only 18% of the UK population but clearly accounted for 90+% of the deaths.

Here is the calculus as I see it:  I was 58 when this all started.  Let's assume I have 20 good years.  Hiding in my home and not doing the things I enjoy for a whole year, as preached by Fauci and company, would have wasted 5% of my remaining life.  Instead, by ignoring them and going about my business, I was taking perhaps a 1/2000 chance of dying to the disease or 0.05% (I actually think given my health and weight that this is exaggerated).  These two numbers are not even close.  They are not one but two full orders of magnitude apart.  When presented with these numbers, and given my preferences, it would have been wildly irrational (or demonstrated extreme risk aversion) for me to follow the advice and dictats of the coronabros.

Well, That Was Fast. UK COVID Strain Likely NOT More Deadly

In my post about the Sunday NY Times article on the B.1.1.7 COVID variant, I expressed skepticism that it really was substantially more deadly than other variants.  While this is possible, on average we expect viruses to mutate in a way that they are more communicable but less deadly (there are no rewards in the parasite world for killing the host).

Specifically I said:

My personal bet is that we will see a story buried on page 34 in August saying that original relative death studies for this [B.1.1.7] variant appear to have been exaggerated.  When the NY Times is hyping a scare story that increases the power of government, particularly in a Democratic administration, take the under.

Well, I was wrong.  Rather than in August, the predicted story was buried in the Wall Street Journal one day later

Clear evidence has emerged that B.1.1.7 transmits more easily than earlier variants, which helped enable its rapid spread. Whether the variant is associated with more severe disease and death has been less certain, however...

In the new study, the researchers took samples collected in early November from 341 Covid-19 patients admitted to University College London Hospitals or North Middlesex University Hospital. The researchers sequenced genetic material from the samples to determine the viral variant that caused the infection, used the test results to estimate how much virus the patients harbored and then compared the two groups.

Nearly 60% of the Covid-19 patients had an infection caused by the B.1.1.7 variant, and patients hospitalized with B.1.1.7 were younger, had fewer health conditions and more often received an oxygen mask than those admitted with other variants, the study found.

Yet the researchers didn’t find that those with a B.1.1.7 infection had more severe disease outcomes such as needing ventilation or dying, after accounting for other factors such as age, ethnicity and underlying conditions.

I will be more careful than the NY Times, who cherry-picked one study result on the far end of the scale of results to date, and acknowledge that the study results -- all based on small samples and uncontrolled population groups -- are mixed.  But evidence both of prior meta-studies as well as this new one give us little reason to believe that this variant is substantially more deadly.

Variant Terrorism and the New York Times

Update:  Just one day after this story, the Lancet published a study showing that B.1.1.7 not likely more deadly than other variants.  As predicted below.

The New York Times has scary red maps of Europe on its front page today (at least in the version we get in AZ) implying mass death from new COVID variants.  Given the prominence of COVID in the news and our lives, there is certainly a story here.  But as usual with American media coverage of COVID, there is absolutely no balance here.  The article highlights new developments in the virus, which is helpful, but does so in a largely data-free manager and simultaneously engages in the crudest of rhetorical tricks to make the situation seem far worse than it is.  Here are a few pointers to how to read through this mess.

  • The use of color on the front page maps is not accidental.  When the media wants you to be scared, it uses red on maps and scales it so that even small changes in variables result in a map going from green or white or blue to solid red and orange.    No exception here.  When one glances at the front page, one likely assumes that this is a map of spread of death or new case counts, but in fact it is merely a map of one new variant as a percentage of other new variants.  It says nothing about death or case counts.

  • The article attempts to use certain rhetorical framings to imply that increases in cases and/or deaths are due to this new variant.  For example:

The variant is now spreading in at least 114 countries. Nowhere, though, are its devastating effects as visible as in Europe, where thousands are dying each day and countries’ already-battered economies are once again being hit by new restrictions on daily life.

and this even more egregious example:

What happened this winter in the U.K. was mass death and deluged hospitals on a scale not seen earlier in the pandemic. Since B.1.1.7 was first sampled in late September, 85,000 people have died. Four million people — one out of every 17 Britons — have recorded infections.

So 85,000 people died from this variant?  Well, they want you to think that -- but they were careful that while implying that (which would not at all be true) they do not actually say that.  When you think about it - especially given that there are now dozens of COVID variants - this sentence means exactly nothing.  It's like saying that since Biden took office, thousands of people have died of cancer.  Here is the UK deaths chart (from Google, not in the NY Times article):

You would certainly never know from this article that deaths in the UK have basically gone to zero.  This chart shows exactly the same seasonal pattern we are seeing everywhere, including in places like Arizona where we have had few if any of this new variant.  This picture has become the great totalitarian Rorschach test of the 21st century, with everyone reading their own preferred causes into these seasonal humps (opened too soon! variants! spring break! evil Republican governor!)

By the way, I will save you clicking through the Times link above that says "mass death and delayed hospitals" in an attempt to see the data.  There is none. Just like with the overloaded hospital meme in the US, the article is quotes from a few harried doctors and funeral home managers and zero data.  The first "overloaded hospital" story I see with actual occupancy numbers compared to the same months in prior years will be the first.   In this case there really is no excuse for this, as the NHS apparently keeps pretty detailed daily hospital records and puts them all online here.  So I looked at the week including January 21, which looks like the peak of critical care at least in the death chart.  On 1/21/21, there were apparently 3 acute and emergency care diverts in the whole of England, and it is not even clear if these were due to capacity issues.  Other days that week were generally on 3 as well (I don't know how they count so I don't know if these are the same 3 people all week or different people each day).  Occupancy of acute and emergency beds was around 87%.  For comparison, the January 2019 report from the same site showed acute and critical care occupancy of 85%.  The site cautions that with the segregation of COVID and non-COVID patients, capacity is harder to manage (a basic tenant one learns in any operations course) but it is hard to gauge by how much.  But all this sort of discussion and outlining of facts that are so easy to find is missing from the article, as the whole point is to scare, not to inform.  After all, reciting statistical facts about vampire incidents is not the best way to tell a scary ghost story around the camp fire.

  • The article keeps saying that this variant is thought to be more transmissible and more deadly.  Towards the very end they get the most specific when they say:

The variant is believed to be about 60 percent more contagious and 67 percent deadlier than the original version of the virus. 

If you follow the link, you have to go through an Easter egg hunt of clicks, but eventually one gets to this metastudy looking at a number of results.   I am not even going to pretend to have expertise in reading and interpreting these results, but I would observe that a) the claimed 67% number seems at the high end of a lot of the results; b) 67% is awfully precise for studies who summarize their study results as this variant "may" and "probably" be more deadly; and c) the sample sizes here are really small and pretty skewed (most seem to be dealing with people already hospitalized or at least showing symptoms).    My personal bet is that we will see a story buried on page 34 in August saying that original relative death studies for this variant appear to have been exaggerated.  When the NY Times is hyping a scare story that increases the power of government, particularly in a Democratic administration, take the under.

  • My understanding is that most deadly viruses tend to mutate over time to be less rather than more deadly.   More transmissive but less deadly is the ideal for a virus trying to spam copies of itself across the globe.  I have yet to see any discussion in any article of this fact along with any hypothesis of why COVID might be behaving differently (since according to the media every damn variant is more scary than the last one).  There may be a reason, and it would be an interesting discussion -- as well as an obvious on of interest to readers -- but I have yet to see it.

I really should not get that worked up about all this -- after all, my blog certainly is not even-handed.  But my concern is

  1. The undercurrent of all these stories is essentially "so shut up and obey."
  2. No criticism or skepticism is being allowed by most of the major gatekeepers.  I can say this kind of stuff because I have a small audience, but once one gets any sort of prominence, such skepticism no matter how well-grounded in facts will be memory-holed.  Take this story.  The claim that children don't need masks is perfectly justifiable for a disease that is deadly for octogenarians but milder than the flu for kids.  We could have a discussion about this and people can disagree, but it is a totally reasonable topic for public discourse.  To ban this can't be due to science, it can only be a quasi-totalitarian deference to authority -- President Biden says we need masks so no one should publicly disagree with him.

Be warned -- totalitarians have not missed the significance of this nor that the government seems to be getting away with it.  You are going to see a spate of issues all reframed as public health issues -- guns, race, climate, immigration -- with folks claiming that newly established COVID-related dictatorial powers need to be applied to their pet issues as well,

I don't think in the history of this country the general populace** has been subjected to the sorts of limitations to individual freedoms that have been imposed over the last year, often by executive order without even involvement of the legislature.  Sometimes by public health officials who are not even elected.  Even in wartime I can't think of any affront to individual liberties that was as bad as the combination of lockdowns, school closures, and business closures.  To have all that happen is bad enough.  But to have the gatekeepers of the public discourse declare that not only are we going to do all these unprecedented authoritarian things, but we are not even going to allow public skepticism of them --that is really scary.  Historically, all the worst ideas have been accompanied by bans on public criticism.

** Clearly minority populations have been subjected to worse.  Enslavement of African-Americans, internment of Japanese-Americans, and near-genocidal actions taken against various native American groups come to mind.